January 31, 2025
3 I will read the smallest
What is JOURNAVX, a new opio -free painkiller from the top?
Non -heated analgesics (Journavx) is as effective for acute pain as common opioid treatment.
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For the first time in 25 years, the US Food and Drug Administration has approved a new type of painkiller. SUZETRIGINE, which is sold as a JOURNAVX, is administered twice a day with an oral tablet of 50 milligrams to treat moderate severe acute pain.
Clinical trials showed that drugs attenuated as effectively as the opiodobase painkillers. And probably the most important thing is to do without the same risk of poisoning.
How does Suzetrigine work?
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Drugs attenuate the signal of pain before reaching the brain. It prevents the nerve cells of the entire body from igniting by blocking the so -called sodium ion channel. These channels are embedded in the film of nerve cells, and by opening and closing, they carry electrical impulses along the nerves.
(Read how a researcher finds a link between sodium ion channel and pain disorders thanks to young Pakistani firerers and “Mann -ON Fire” syndrome.)
Pharmaceutical companies have been trying to create painkillers targeting sodium ion channel for decades, but the development pipeline has been depleted most after many wrong starts. They have finally succeeded in SUZETRIGINE, developed by Pharmaceutical Company Vertex.
The approval of the FDA is based on the two phase 3 clinical trials performed in the tummy tack and the patient after the aponeuromen removal surgery. In both examinations, about 1,000 patients were combined with the Opioid Hydrokodon and acetaminophen, which had been sold as a vicodin, formerly a vicodin. Suzetrigin and opioid treatment decreased by about 3 points on standard 10 points of pain. Suzetrigine worked faster and has less side effects.
Why is the Suzetrigin so important?
For decades, people who have been painful have two options. It is one of the limited -edition medicines that provide limited relaxation, including acetaminophen and non -steroidal anti -inflammatory drugs (NSAID) such as aspirin and Ibuprofen. The other is an opioid, and there is a risk of adverse effects on addiction and side effects. With these limited options, the opioid is the only option for many people who experience serious pain, whether acute or chronic, killing more than 100,000 people in the United States every year and destroying the community. Promoted the opioid crisis.
SUZETRIGINE offers a very newly tested new drug and for those who want pain relief. This drug functions only in peripheral nerve cells and does not function in the brain or spinal cord, so there is no risk of poisoning by opioids.
Suzetrigin is approved only to treat acute pain, but the vertices report positive results from the test of drug safety and effectiveness of people who experience chronic pain from diabetic peripheral neuropathy. Masu. Clinical trials of phase 3 are currently ongoing. Other companies are also developing drugs targeting sodium -ion channel in various ways.
“We are definitely hoping that we can replace the opioid, which is the goal here,” said Nabega Serapytics Ana Moreno, told journalist Mara Broadfoot. Scientific American These sodium ions -articles on the promise of channel blocks.
What are the side effects of Suzetrigin?
Among the test participants, the most common side effects of drugs were the level of itching, muscle cramps, and the level of creatine phosphate in the blood. Pharmacotherapy should not be taken side by side with other drugs that strongly inhibit the enzyme called CYP3A, which contains some antibiotic and antiviral agents. Suzetrigin people should not eat grapefruit.
(Read more: “Why grapefruit hinders medicine, and what to do about it.”)
According to Vertex, the drug can be used for $ 15.50 per 50 milligram or about $ 30 per day. In contrast, the average dose of retailing the combination of hydrocodon and acetaminophen is about $ 7 per day. It is still unknown how the insurance company and Medicare cover the suzetrigin.
